Experience with isolated limb perfusion
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منابع مشابه
Isolated limb infusion for melanoma: a simple alternative to isolated limb perfusion.
OBJECTIVE To describe initial experience with the new technique of isolated limb infusion (ILI) for in-transit melanoma. DESIGN A prospective case series. SETTING The major tertiary care oncology centre for the state of Victoria, Australia. PATIENTS Nine patients having for extensive in-transit limb melanoma INTERVENTIONS All patients received ILI (13 treatments). OUTCOME MEASURES Pat...
متن کاملHyperthermic isolated limb perfusion for recurrent melanomas and soft tissue sarcomas: feasibility and reproducibility in a multi-institutional Hellenic collaborative study.
Hyperthermic isolated limb perfusion with TNF-alpha and melphalan (TM-HILP) is a complicated surgical procedure. Herein, we present the experience of the Hellenic collaborating centers with TM-HILP for inoperable in-transit melanoma and soft tissue sarcoma (STS) of the extremities to examine safety and feasibility of collaborating as a multi-institutional group for future research studies. From...
متن کاملAn Improved Method for Injection of Bolus Doses of Drugs into the Perfusion Circuit of Isolated Perfused Rat Kidney Utilizing a Six-port Injection Valve
The isolated perfused rat kidney experiment was introduced in 1959 for studying the regulation of renal blood flow and is recognized as a valuable preparation for studying physiological and biochemical aspects of renal function such as hemodynamics, glomerular filtration rate (GFR) and overall handling of fluids. Dose-response curves are obtained by injection of bolus doses of drugs into the pe...
متن کاملHyperthermic isolated perfusion with tumor necrosis factor-alpha and doxorubicin for the treatment of limb-threatening soft tissue sarcoma: the experience of the Italian Society of Integrated Locoregional Treatment in Oncology (SITILO).
BACKGROUND Tumor necrosis factor-alpha (TNFalpha)-based hyperthermic isolated limb perfusion (HILP) is routinely carried out at most oncological institutions in the treatment of locally advanced soft tissue limb sarcoma (STS), employing high TNFalpha dosages. After a phase I-II study, the SITILO (Italian Society of Integrated Locoregional Therapies in Oncology) centers began to employ the lower...
متن کاملDesflurane as a marker of limb-to-systemic leak during hyperthermic isolated limb perfusion.
SOME malignancies of the extremities can be treated by hyperthermic isolated limb chemotherapy. This procedure involves arterial and venous cannulation of the affected limb and isolated perfusion using a bypass pump. When a steady state is reached, the blood is warmed and oxygenated, and a chemotherapeutic agent (e.g., melphalan) is added and circulated in the limb for up to 1 h. Because the li...
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تاریخ انتشار 2017